Essential Endocrinology and Diabetes 6th
Edition PDF
 |
| Essential Endocrinology and Diabetes 6th Edition PDF |
Preface
There have been significant advances and developments in the 4 years since we wrote
the last edition. Consequently, many areas of the book have required substantial updating
and extensive re-writing. Nevertheless, the structure of the book has remained similar
to the last edition, which seemed popular around the world.
The first part strives to create a knowledgeable reader prepared for the clinical sections.
Recognizing that many students now come to medicine from non-scientific
backgrounds, we have tried to limit assumptions on prior knowledge. For instance, the
concept of negative feedback regulation, covered in Chapter 1, is mandatory for understanding
almost all endocrine physiology and is vital for the interpretation of many
clinical tests. Similarly, molecular diagnostics has advanced far beyond the historical
development of immunoassays. New modalities, such as molecular genetics, mass spectrometry
and sophisticated imaging, are already standard practice and it is important
that aspiring clinicians, as well as scientists, appreciate their methodology, application
and limitations. The second part retains a largely organ-based approach. The introductory
basic science in these chapters aims to be concise yet sufficient to understand,
diagnose and manage the associated clinical disorders. The chapter on endocrine neoplasia,
including hormone-secreting tumours of the gut, has been expanded in recognition
of the increasing array of hormones discovered from the pancreas and gastrointestinal
tract. In previous editions these hormones have lacked attention. However, many of
them are now emerging as key regulators that are exploited in new therapies. For
instance, augmentation of glucagon-like peptide 1 signalling is an effective treatment for
diabetes. The third part on diabetes and obesity was entirely new in the last edition and
these chapters have undergone the greatest change here. Over the last 4 years we have
seen significant advances in the treatment of type 2 diabetes such as the new incretinbased
therapies and the withdrawal of other treatments due to safety concerns. Clinical
algorithms have also changed and these have been updated…
the last edition. Consequently, many areas of the book have required substantial updating
and extensive re-writing. Nevertheless, the structure of the book has remained similar
to the last edition, which seemed popular around the world.
The first part strives to create a knowledgeable reader prepared for the clinical sections.
Recognizing that many students now come to medicine from non-scientific
backgrounds, we have tried to limit assumptions on prior knowledge. For instance, the
concept of negative feedback regulation, covered in Chapter 1, is mandatory for understanding
almost all endocrine physiology and is vital for the interpretation of many
clinical tests. Similarly, molecular diagnostics has advanced far beyond the historical
development of immunoassays. New modalities, such as molecular genetics, mass spectrometry
and sophisticated imaging, are already standard practice and it is important
that aspiring clinicians, as well as scientists, appreciate their methodology, application
and limitations. The second part retains a largely organ-based approach. The introductory
basic science in these chapters aims to be concise yet sufficient to understand,
diagnose and manage the associated clinical disorders. The chapter on endocrine neoplasia,
including hormone-secreting tumours of the gut, has been expanded in recognition
of the increasing array of hormones discovered from the pancreas and gastrointestinal
tract. In previous editions these hormones have lacked attention. However, many of
them are now emerging as key regulators that are exploited in new therapies. For
instance, augmentation of glucagon-like peptide 1 signalling is an effective treatment for
diabetes. The third part on diabetes and obesity was entirely new in the last edition and
these chapters have undergone the greatest change here. Over the last 4 years we have
seen significant advances in the treatment of type 2 diabetes such as the new incretinbased
therapies and the withdrawal of other treatments due to safety concerns. Clinical
algorithms have also changed and these have been updated…
Essential Endocrinology and Diabetes 6th Edition EBook
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